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Monitor Intently (1)crofelemer will increase amounts of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Crofelemer has the potential to inhibit CYP3A4 at concentrations envisioned within the gut; not likely to inhibit systemically for the reason that minimally absorbed.Severe - Use Alternate (1)aluminum hy